Leptin modification in chronic myeloid leukemia patients treated with imatinib: An emerging effect of targeted therapy.☆
نویسندگان
چکیده
We evaluated serum leptin levels in 9 young chronic myeloid leukemia (CML) patients under imatinib therapy during a long-term follow-up. Body mass index (BMI) and fat mass percentage (%FM) were also measured. Leptin was above the normal range in 8 out of 9 patients. In one case the hormone was below the reference value. All subjects showed a normal BMI, but 3 had a small increase of FM%. One patient recovered the leptin normal value after imatinib suspension. A tendency to leptin normalization in patients switched to an intermittent therapy was also found. This study suggests that imatinib therapy may result in leptin alteration.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013